Please discuss the mechanisms that Bordetella pertussis, Streptococcus pneumoniae, Corynebacterium diphtheriae and Mycobacterium tuberculosis utilize to cause disease in the respiratory tract. You must state what disease these microorganisms cause and what role does transduction play in their disease causing process. In addition, please discuss the host immune defenses the microbes would have to overcome to be successful at causing disease. Also, please discuss what the microbe could contain that would allow them to overcome these host immune responses, and the association between normal flora and respiratory tract infections. Include a discussion what roles personal hygiene, quorum sensing and sequential timing play in microbial respiratory tract diseases. What’s a receptor-mediated process? What’s the significance of SOD and catalase to the pathogenesis of Bordetella pertussis? What’s an obligate aerobe? What’s generalized and specialized transduction and their significance to the pathogenesis of Streptococcus pneumoniae and Corynebacterium diphtheriae?
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